Top 10 Medical Billing Software in the USA 2025

Choosing the right medical billing software can help your healthcare practice work efficiently. Billing software simplifies the work by automating claims, improving accuracy, and enhancing revenue cycles through payment processing.

Several medical billing software programs with various features are tailored to provide billing solutions for healthcare professionals across all practices.

In this blog, we’ll know about the top 10 medical billing software in the USA, focusing on benefits and features that help providers streamline their workflow and enhance revenue cycle.

What is Medical Billing Software

Medical billing software is an application designed to streamline and automate the billing process for healthcare providers. It plays a significant role in managing financial operations by handling a wide range of tasks.

It encompasses claims submission, insurance verification, coding support, denial handling, payment processing, and revenue reporting. Billing software connects with EHR systems to easily access patient records and billing information.

By automating these administrative functions, medical billing software reduces manual effort, minimizes errors, and ensures faster reimbursements. It supports healthcare practices and billing companies in optimizing revenue cycle management, improving overall efficiency, and financial performance.

Related: The Definitive Guide to Medical Billing

Leading Healthcare Billing Software in the U.S. 2025

1. DrChrono

DrChrono was founded in 2009, It is a California-based company that provides integrated EHR and medical billing software for small to medium-sized healthcare practices. It includes seamless integration of EHR, medical billing, and scheduling options. DrChrono processes the billing cycle from appointment to payment.

Features of DrChrono 

• DrChrono’s billing profile reduces data entry and sets up your most common diagnosis and medical billing codes.
• Real-time Insurance Eligibility checks whether you are eligible for the insurance during the appointment process. 
• The Denial Analysis tool generates reports for which services or codes the claims are denied.

2. AdvancedMD

In 1999, AdvancedMD was founded. AdvancedMD is a cloud-based electronic health record with management features and billing designed for small to medium-sized healthcare practices.

It automates the billing process and reduces manual errors. It offers financial analytics, scalable for all sizes of practice, and improves workflow with integrated scheduling and clinical tools.

Some of the features include

• Integrated credit processing helps staff quickly collect balances and post payments.
• Online charge slips can be used for post-procedure and set alerts for codes that require follow-ups.
• Reporting Software measures your success and increases your revenue with analytics and reporting tools.

3. Kareo

Kareo Billing is a cloud-driven billing solution established in 2004, aimed at independent practices. It operates on day-to-day tasks, enhancing revenue collections. The platform allows users to track payments in real time, send electronic claims, and manage authorizations in one place. It reduces manual work and saves time with automated tools.

Features of Kareo Billing 

• Kareo provides real-time claim tracking and eases the process.
• Integrated with billing analytics tools provides billing snapshots of collections.
• Smart checks are incorporated into its billing workflow to process claims.

4. NextGen Healthcare

NextGen Office was formed in 1976, offers a user-friendly cloud-based EHR and billing platform. It integrates clinical, financial functions for a smoother workflow. It enhances billing accuracy and reduces denials. Its streamlined billing process saves time. It also provides training and implementation support.

Features of NextGen Healthcare

• NextGen Healthcare offers simple-to-use workflows for processing and faster claims submissions to drive increased revenue and profitability.
• Accurate claim submissions are maintained using current patient data and encounter claims codes.
• They have convenient patient payment options, claims get processed quickly, and are paid sooner.

5. eClinicalWorks

eClinicalWorks was founded in 1999 and is the largest cloud-based EHR system in the United States, providing EHR and strong practice management features. Over 110,000 facilities run on this system, and it caters to the specific needs of various healthcare specialties. It optimizes insurance claims and revenue cycles.

Features of eClinicalWorks

• Automated workflow, registration, and claim edit rules from inputs and analyzes CPT codes to generate and suggest rules to minimize denials.
• ERAs are generated when there are no options from the payor, and they reduce the manual posting of EOBs. 
• Billing responds to natural language questions about claims, payments, refunds, or alert dashboards, eliminating manual searches.

6. Epic Systems

Epic Systems was founded in 1979 and is one of the leading EHRs and the best medical billing software offering integrated medical billing functionalities. The medical billing module seamlessly integrates with the EHR system, which allows claim management, RCM. Epic can be used in multi-specialty hospitals. It provides a smooth process from billing to patient care.

Features of Epic Systems

• Epic verifies insurance electronically and eliminates the need for separate payor portals, saving your staff time with seamless interoperability with other systems.
• They offer customizable billing workflows, which help you in the revenue cycle.
• Epic Systems confirms eligibility, expedites claims payments, and has self-pay options.

7. Practice EHR

Practice EHR was founded in 2014. It is a cloud-based system specially built for small to medium-sized practices. It provides EHR, billing, and practice management in a single platform. The system automates claims, reducing billing time. Improves accuracy with real-time data insights, enabling seamless sharing between systems. 

Features of Practice EHR

• Practice EHR has certified billers and medical coders with extensive experience and flexible service options.
• They offer total transparency, granting access to the full billing process, your practice’s financials, ongoing denials and appeals, payments, and adjustments.
• Verifying eligibility in real-time, electronic claim submission increases the rate of clean claims with automated claim scrubbing.

8. athenaCollector

athenaCollector was founded in 2000 by athenahealth, focusing on medical billing and high-level automation. Increases collection through real-time claim processing and reduces denials with billing tools. AthenaCollector enhances transparency throughout the process with custom dashboards. They ensure security compliance with HIPAA regulations.

Features of athenaCollector

• Real-time eligibility verifies patient insurance coverage and minimizes claim denials.
• Automates claim submissions, payment processing and reduces administrative work.
• Optimized medical billing speeds up the reimbursement processes, leading to improved cash flow.

9. Practice Fusion

Founded in 2005, Practice Fusion is a prominent EHR that operates in the cloud. The firm, established in San Francisco, originally sought to make healthcare easier for small and independent practices.

Features of Practice Fusion

• Assist in patient communication with a choice of electronic or paper patient statements.
• Manages insurance and patient payment posting, insurance AR follow-up, refunds and credit management, as well as denial management.
• Coordinates with payors via a payor dashboard, payor compliance tools, and claims scrubbing on the same day of claim submission.

10. CureMD

CureMD was founded in 1997, a cloud-based medical billing software used in various healthcare institutions. It offers integrated EHR, revenue cycle services. CareMD practice management system enhances billing and financial reporting.

Features of CureMD

• CureMD enhances revenue with real-time claim scrubbing and billing solutions to minimize claim denials.
• Medical billing services are provided for every specialty, including cardiology, radiology, neurology, and nephrology.
• They provide accuracy and optimized financial performance through RCM services.